PSA is a protein produced by the cells of the prostate gland. Normally PSA is involved in the dissolution of the seminal fluid coagulum and it plays a role in fertility. Highest amounts are found in the seminal fluid but low levels do enter the blood stream of a normal male.
PSA levels are found to be useful in screening men for prostate cancer. It is often elevated in the presence of prostate cancer but is also elevated in disorders such as benign prostatic hyperplasia (BPH) and acute bacterial prostatitis.
The U.S. Food and Drug Administration (FDA) has approved PSA tests for annual screening of prostate cancer in men of age 50 and older. The most valuable measurement of PSA is its change over time rather than the actual serum level.
Assays for total PSA (tPSA) are based on the detection of 2 major forms:
- Free, or uncomplexed (fPSA)
- Complexed, the dominant form of PSA bound to α1-antichymotrypsin (PSA-ACT)
Meridian Life Science, Inc. is introducing a group of Monoclonal Antibodies (MAbs) to PSA that are specific for tPSA. These MAbs were characterized in ELISA to offer you antibody pairs that detect either tPSA or fPSA.
For more information including pricing and availability, please contact us at email@example.com.
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Meridian Life Science, Inc.