Home » Services » Custom Assay Development » Biologics R&D and Process Development » Upstream Processing

Meridian Biologics has a 22 year history of cell culture experience that can be applied to your protein production needs. Our staff of Virologists, Cell Biologists, and Microbiologists are dedicated to our client's needs and to providing the highest quality product possible.

Process Development Services
We can start with your traceable cell line or even your DNA sequence and generate Master and Working Stocks for production of recombinant proteins in our dedicated Eukaryotic or Prokaryotic suites.

•	Seamless tech transfer from development to clinical production.
•	Reduced production cost via development of optimal high yield bacterial, yeast, and insect cell expression systems.
•	Ability to conduct "In-Parallel" cell line optimization using multiple cell lines simultaneously to reduce "time to cGMP."
•	Cloning strategy and expression system development for high-level production of active, functional proteins.
•	Selection of optimal clones and expression systems.
•	Prokaryotic cGMP fermentation from 35 to 60 liters.
•	Eukaryotic culture in roller bottles.
•	Eukaryotic culture in 1 to 4 WAVE Bioreactors (25 liters each). Batch, Fed Batch, and Perfusion Culture Experience.
•	Conversion of hybridomas for production in cell culture.
•	Media optimization.
•	Centrifuges for cell pelleting.
•	Plaque assay and end point dilution for determination of viral titer. New assays can be developed to fulfill any requirement.

About Us • Products • Services • Orders • Technical Resources • Contact Us